| Gene name: | PML |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MRC-5,WI-38 |
| Experiment: | SA-β-gal activity assay//Western blot//Knockdown |
| Description: | Strikingly,PML knockdown caused a dose-dependent decrease in cell proliferation, morphological changes consistent with a senescent phenotype and an increased expression of the senescence-related β-galactosidase enzyme.Moreover, a senescence molecular pathway was activated, as shown by an increased expression of the p53, p16INK4aand p21WAF1proteins in PML-depleted cells with respect to control cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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