| Gene name: | NBNC |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Fibroblast |
| Gene ID: | 4683 |
| Category: | protein coding |
| Phenotype: | Nijmegen Breakage Syndrome |
| Experimental category: | L |
| PMID: | 22161642 |
| Experiment: | SA-β-gal activity assay |
| Description: | When comparing the telomere attrition rate, we foundthat NBS cells showed a higher telomere shortening rate compared to that in normal cells in vitro. For each replication cycle, the telomere shortening rate of NBS cells is around 30bp faster than that of its respective normal counterparts. Consistent with the accelerated telomere shortening, NBS fibroblasts exhibited a significantly higher percentage of cells undergoing senescence compared to normal cells with the same PDLs. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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