| Gene name: | HMGA2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | ULM |
| Gene ID: | 8091 |
| Category: | protein coding |
| Phenotype: | Uterine leiomyomas |
| Experimental category: | HL |
| PMID: | 29790226 |
| Experiment: | Knockdown//SA-β-gal activity assay |
| Description: | Cells treated with HMGA2 siRNA had significantly increased levels of β-Gal staining, indicative of cellular senescence than the cells treated with control siRNA. |
| Target gene: | P16//P21 |
| Official symbol(s): | P16//P21 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | In addition, we observed that silencing of HMGA2 in ULM led to upregulation of both p16 and p21. |
| Regulatory pathway: | AKT |
| R-AG-Pathway: | -- |
| Official symbol(s): | AKT1 |
| Pathway experiment: | Western blot//Knockdown |
| Pathway description: | A dose-dependent upregulation of pAKT was observed by Western blot analysis along with an increase in HMGA2 levels. Next, using HMGA2 ULM, HMGA2 was silenced using siRNA. With decreased HMGA2 levels, decreased pAKT levels were observed . |
Annotation:
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