| Gene name: | ADIPOQ |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Liver |
| Cell name: | -- |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | The number of SA-β-gal positive cells in liver tumor tissue from APN KO mice was markedly less compared with that from WT mice, indicating that adiponectin promotes cell senescence in tumor tissues. |
| Target gene: | CXCL1 |
| Official symbol(s): | CXCL1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR |
| Target gene description: | qPCR analysis further confirmed that CXCL1 was highly up-regulated in the adiponectin-treated SL4 cancer cells. |
| Regulatory pathway: | P53//P16 |
| R-AG-Pathway: | Activation//Activation |
| Official symbol(s): | TP53//CDKN2A |
| Pathway experiment: | Immunohistochemistry//Immunofluorescence |
| Pathway description: | p53- and p16-positive cells was detected in adiponectin treated co-cultured cells but not without adiponectin treatment, no expression was detected for p19 and p21 moleculars. Moreover, immunostaining of cocultured cells with PDGFRa (a marker of fibroblasts) confirmed the p53- and p16-positive cells are fibroblasts. Intervention experiments also showed p53 and p16 were involved in angiogenesis and tumor growth. |
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