| Gene name: | BMP7 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HeLa,PMC42 |
| Gene ID: | 655 |
| Category: | protein coding |
| Phenotype: | Cervical cancer |
| Experimental category: | L |
| PMID: | 19010887 |
| Experiment: | Telomerase activity assay//Telomere length assay |
| Description: | Incubation of human cervical cancer HeLa cells with different concentrations of BMP7 for 48 hours resulted in significant inhibition of telomerase activity.BMP7 induced significant inhibition of telomerase activity in a dose-dependent manner in PMC42 cells.Analyzing the mean telomere length in control and BMP7-treated cells showed that the mean telomere length in the BMP7-treated group could be f25% shorter than that in the controls. |
| Target gene: | HTERT//C-MYC |
| Official symbol(s): | HTERT//C-MYC |
| R-AG-Target gene: | Downregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR |
| Target gene description: | BMP7 induced a significant downregulation of hTERT gene expression in both HeLa and PMC42 cells.We noted that BMP7 also induced a significant down-regulation of c-myc gene expression . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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