| Gene name: | CSNK2A1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | A172,U87 MG |
| Gene ID: | 1457 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | HL |
| PMID: | 22318540 |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | Treatment with Pifithrin-α reversed CK2-I-induced cell cycle arrest. Similar results were obtained in U87 cells also (data not shown). The increase in senescence-positive cells observed in cells treated with CK2-I both in the presence and absence of TNFα, was abrogated in the presence of Pifithrin-α. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | A dramatic increase in p53 levels accompanied with an increase in phosphorylation (Ser-15) and acetylation (Lys373, 382) of p53 was observed upon treatment with CK2-Is either alone or in the presence of TNFα. CK2-Is either alone or in combination with TNFα increased mRNA levels of p53-induced pro-apoptotic molecules GADD45β and Noxa. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...