| Gene name: | TERT |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | mTert?/?Fibroblast |
| Experiment: | Western blot |
| Description: | In mTert-/- cells, the levels of the senescence biomarkers p53 and p21 were increased sharply at the M stage, in response to critically shortened telomeres at the same stage. However, unlike mTert -/- cells, the activation of the p53/p21 pathway in mTert+/+ cells immediately triggered the DDR response and up-regulated the expression of ATM, PARP1, and CHK1 at the M stage, and their elevated expressions were maintained through the L stage. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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