| Gene name: | ARG2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | The senescence markers such as the number of SA-β-gal positive cells,the levels of p53-S15 and p21Cip1 as well as levels of VCAM1 and ICAM1 are significantly augmented by Arg-II overexpression. |
| Target gene: | ENOS |
| Official symbol(s): | ENOS |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Immunostaining |
| Target gene description: | Conversely, in nonsenescent cells, adenovirus-mediated ectopic expression of a wild-type (WT) Arg-II cDNA as verified by immunoblotting,leads to eNOS-uncoupling, i.e., impaired NO production (DAF-2DA staining) and enhanced intracellular O2-generation (DHE staining),which is significantly inhibited by the eNOS inhibitor L-NAME. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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