| Gene name: | DUSP |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | RPMI8226 |
| Gene ID: | 17362377 |
| Category: | protein coding |
| Phenotype: | Myeloma |
| Experimental category: | L |
| PMID: | 30280787 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | The increase of DUSP evidently elevated the expression of P53, while reduced the level of TLR4. However, the block of DUSP reversed the effect on P53 and TLR4, indicating that DUSP participated in H2O2 induced myeloma cell line RPMI8226 aging and might regulate the level of TLR4. |
| Regulatory pathway: | TLR4 |
| R-AG-Pathway: | Downregulation |
| Official symbol(s): | TLR4 |
| Pathway experiment: | Western blot |
| Pathway description: | The increase of DUSP evidently reduced the level of TLR4. |
Annotation:
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