| Gene name: | RRN3 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF-7,MEF |
| Experiment: | SA-β-gal activity assay//qRT-PCR//Western blot//Immunostaining |
| Description: | We found that RPL11 depletion suppressed the accumulation of p53, p21, and p16, and the number of SA-β-gal-positive cells induced by TIF-IA overexpression . We depleted RPL11 in the presence of small interfering RNAs (siRNAs) specific for DKC1, RRP5, and RRS1, any of which induced p53 accumulation, p21 induction, p16 induction, and cellular senescence.We found that RPL11 depletion abrogated these events. |
| Regulatory pathway: | P53-P21 |
| R-AG-Pathway: | Activation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | SA-β-gal activity assay |
| Pathway description: | As with the case of TIF-IA overexpression, the increased number of SA-β-positive cells by the depletion of the rRNA-processing factors was counteracted by p53 or p21 depletion . |
Annotation:
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