| Gene name: | ATM |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Human haired scalp |
| Cell name: | HFMs |
| Experiment: | IHC//Western blot//Cell viability assay |
| Description: | The intensity and the distribution level of the staining of TRP-1 and GP100 was higher in the hair ?follicle melanocytes of fully pigmented follicles, sporadic in melanocytes with reduced pigmentation and lack?ing in weakly pigmented/white hair follicles.Results showed increased total ATM levels in HFMs afer H2O2 treatment, and this increase was blocked by pre?incubation of HFMs with antioxidants VitE/Q for 1h.Both Menadione and H2O2 treatment ?signifcantly reduced cell viability versus vehicle controls.As seen in Fig. 5, results showed that in the absence of ATM kinase activity, sustained H2O2 treatment for 24 h significantly reduced cell viability compared to controls. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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