| Gene name: | CLOCK |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HMSC |
| Experiment: | SA-β-gal activity assay//Clonal expansion assay//RT-qPCR |
| Description: | Increased SA-β-gal activity, decreased proliferative potential, and decreased percentage of S-phase cells were detected in CLOCK–/– hMSCs. CLOCK deficiency resulted in the enhancement of DNA damage response and SASP. we observed downregulated transcription levels of LMNB1 and TMPO and upregulated mRNA expression of the aging markers CDKN1A (P21) and CDKN2A (P16) in CLOCK–/– hMSCs. |
| Target gene: | LAMIN B1,EMERIN,KAP1 |
| Official symbol(s): | LAMIN B1,EMERIN,KAP1 |
| R-AG-Target gene: | --//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Co-IP |
| Target gene description: | Co-immunoprecipitation (Co-IP) assays verified these new interactions between CLOCK and nuclear lamina/heterochromatin-associated proteins in HEK293T cells and hMSCs. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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