| Gene name: | ABI3 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | ARO,WRO |
| Experiment: | Cell proliferation assay//Flow cytometry//Cell cycle analysis//SA-β-gal activity assay |
| Description: | Although we observed a trend toward increased apoptosis in WRO cells expressing ABI3 when compared to control cells, the growth attenuation was, however, not accompanied by a corresponding increase in apoptotic cells.The ABI3-induced growth suppression in was further studied by flow cytometric analysis, which revealed a decrease in cell viability and cell cycle arrest at the G0/G1 phase.The number of β-Gal positive cells was higher in ARO and WRO cells expressing ABI3 at days 3 and 5 postseeding. |
| Target gene: | P21//E2F1 |
| Official symbol(s): | P21//E2F1 |
| R-AG-Target gene: | Upregulation//Downregulation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | RT-PCR |
| Target gene description: | Stable expression of ABI3 in WRO cells induced p21WAF1 while reduced E2F1 expression at days 3 and 5 post-seeding. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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