| Gene name: | MAPK1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Fibroblast |
| Gene ID: | 5594 |
| Category: | protein coding |
| Phenotype: | Prostate cancer |
| Experimental category: | HL |
| PMID: | 23599344 |
| Experiment: | SA-β-gal activity assay//Knockdown//Western blot |
| Description: | ERK2 knockdown in cells expressing RasV12 inhibited the induction of senescence-associated β-galactosidase (SA-β-Gal), PML bodies, and DNA damage foci.Oncogenic ras engaged the p53/p21, p16INK4a/RB, and p38MAPK pathways in primary cells, and this was efficiently prevented by knockdown of ERK2.The induction of several senescence-associated cytokine genes by RasV12 was also efficiently blocked by ERK2 knockdown. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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