Aging Overview

Aging gene

Gene name: MALAT1
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: GBC-SD,SGC-996
Gene ID: 378938
Category: ncRNA
Phenotype: Gallbladder cancer
Experimental category: HL
PMID: 31174563
Experiment: SA-β-gal activity assay//EdU assay//Transwell assay//Western blot
Description: Our results indicated that when MALAT1 was silenced, the viability of the GBC-SD and SGC-996 cells was suppressed, and the expression of Ki67 and PCNA was reduced. Meanwhile, the capabilities of migration and invasion were inhibited, while the SA-β-gal activity was promoted (p?


Regulatory relationship

Target gene: ABI3BP//EZH2
Official symbol(s): ABI3BP//EZH2
R-AG-Target gene: Downregulation//--
Subcategory: Methylation
Target gene experiment: qRT-PCR//Pull-down assay
Target gene description: We carried out the correlation analysis and found that the expression of MALAT1 and ABI3BP was negatively correlated.The binding of MALAT1 to EZH2 was further verified by RNA pull down. The results demonstrated that Bio-MALAT1-WT pull-down more EZH2 relative to that of the Bio-probe and Bio-MALAT1-MUT, suggesting that MALAT1 promoted the enrichment of EZH2. Higher expression of ABI3BP was identified among cells treated with sh-MALAT1 than that in sh-NC.Taken together, a conclusion was drawn that MALAT1 inhibited the expression of ABI3BP by recruiting EZH2 to the promoter region of ABI3BP.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

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