| Gene name: | FN1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U251,T98G |
| Experiment: | SA-β-gal activity assay//qRT-PCR//Knockdown |
| Description: | Compared to that in the blank and NC groups, the cell senescence rate was notably increased in the siRNA-FN1 group, and the expression levels of p16 and p21 were significantly elevated (all P < 0.05). |
| Regulatory pathway: | PI3K-AKT |
| R-AG-Pathway: | Activation |
| Official symbol(s): | PIK3CA-AKT1 |
| Pathway experiment: | Luciferase reporter assay//Western blot//qRT-PCR |
| Pathway description: | Compared to the pGL3- basic group, the luciferase activity of the pGL3-FN1 group was increased in both the U251 and T98G cells. Compared to blank and NC groups, the expression levels of FN1, PI3K, and AKT were all decreased in U251 and T98G cells in the siRNA-FN1 group, but the expression level of PTEN increased. |
Annotation:
Loading,please wait...