| Gene name: | EWSR1 |
| Aging type: | Prevent |
| Aging characteristic: | Others |
| Tissue type: | Blood |
| Cell name: | Lin-Sca1+c-Kit+,BM,HSPC |
| Gene ID: | 2130 |
| Category: | protein coding |
| Phenotype: | Ewing sarcoma |
| Experimental category: | L |
| PMID: | 21030557 |
| Experiment: | SA-β-gal activity assay//Knockdown//Flow cytometry |
| Description: | When we assessed senescence-associated β-galactosidase activity (SA-β-gal), Ews-/- embryos at a late stage of gestation had significantly higher levels of endogenous SA-β-gal activity compared with WT embryos, suggesting that senescence has already begun from prenatal stages.Cell-cycle analysis showed that a substantial number of Lin , Sca-1 , and c-Kit cells (81%) in Ews- /- mice progressed through the G1, S, and G2/M phases, which was in marked contrast with the Ews- /- mice (34% in G1, S, and G2/M). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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