| Gene name: | SORBS2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Primary human keratinocyte |
| Experiment: | SA-β-gal activity assay |
| Description: | The highest number of senescent cells was observed for SORBS2-2 fourteen days after transduction.The characteristic perinuclear β-galactosidase staining pattern of enlarged and flattened cells was observed in case of fibroblasts.In contrast, the morphology of senescing keratinocytes differed in that both enlarged and rounded cells with an overall blue stain were observed. SORBS2-2 and TLR3 could induce senescence in both cell types. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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