| Gene name: | HRAS |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | SA-β-gal activity assay//Flow cytometry//Western blot//Cell morphological analysis |
| Description: | HRasV12 expressing IMR90 cells display the typical hallmarks of a senescent cell, including persistent cell growth arrest, increased activity of senescence-associated β-galactosidase (SA-β-gal) (4.7% in control vs 79.6% in Ras-treated group, P<0.05 ), expression of cell-cycle inhibitors, and levels of the senescence marker H3K9me3, as well as persistent DDR. OIS-induced senescence also significantly increased the mRNA levels of SASP-associated genes by at least 19.7-fold (Illustrated by the case of CXCL6. P<0.05) compared with the control group . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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