| Gene name: | TOPBP1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF,3T3 |
| Experiment: | SA-β-gal activity assay//DAPI staining//Flow cytometry |
| Description: | TopBP1-ablated cells underwent morphological changes including enlargement and flattening of the cells on the culture dishes.TopBP1-ablated cells were positive with respect to SA-β-gal staining,which detects senescent cells.FACS analysis of TopBP1-ablated cells indicates a reduction of G1-phase cells containing 2N DNA and a reduction of S-phase cells as well as an increase of G2/M-phase cells containing 4N DNA content, relative to wild-type cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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