| Gene name: | SETMAR |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U87MG,SF268 |
| Gene ID: | 6419 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | HL |
| PMID: | 32458986 |
| Experiment: | Cell transfection//SA-β-gal activity assay//Western blot |
| Description: | According to experiments, shRNA (sh1) or siRNA (mixture of 3 siRNAs) mediated knockdown of SETMAR initially induced cell death of RR cells; however, eventually (12 days post induction of shRNA and 10-day post siRNA treatment) the cells ceased to grow and became senescent. Importantly, SETMAR knockdown did not alter the growth pattern of parent cells but specifically halted the proliferation of RR cells, highlighting the dependency of RR cells on SETMAR to escape from senescence. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...