| Gene name: | HGF |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | EPC |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | HGF and SOD, but not VEGF, significantly attenuated Ang II–induced senescence of EPCs as determined by senescence associated -galactosidase staining, although HGF and VEGF alone promoted EPC senescence. Moreover, HGF and SOD significantly inhibited the induction of p53, p21Cip1, and p16INK4a by Ang II. |
| Target gene: | RAC1//PIP3//AKT |
| Official symbol(s): | RAC1//IPCEF1//AKT |
| R-AG-Target gene: | --//Downregulation//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Whereas pretreatment with HGF, but not VEGF, prevented Ang II–induced rac1 binding to GTP at 60 minutes. HGF also prevented Ang II–induced rac1 translocation from the cytosol to the plasma membrane.we examined the PIP3 production, and, finally, we found that pretreatment with HGF significantly inhibited Ang II–induced PIP3 production, whereas VEGF did not inhibit it.Consistently, pretreatment with HGF,but not VEGF, significantly inhibited Ang II–induced phosphorylation of Akt in EPCs. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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