| Gene name: | TP53 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | The shorter survival of nontumor-bearing p53S18Amice suggests that their aging process could be accelerated due to the Ser18mutation. In fact, these mice exhibited heightened expression of several factors associated with aging, such as inability to heal, premature graying, chronic alopecia, and lordokyphosis. The number of positive blue cells increased with each passage of p53S18A cells, compared with wild-type cells. By passage 3,30% of p53S18A cells stained positive for β-gal, whereas none of the wild-type cells stained positive . Also, the cells seemed to be mostly large flat cells, which is consistent with cells having exited the cell cycle. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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