| Gene name: | PRDX1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCT116 |
| Experiment: | Knockdown//Southern blot//TRF analysis//Southern hybridization |
| Description: | The MTH1 knockout clone lost 15 base pairs(bp) of telomeric DNA per population doubling (PD),and the PRDX1/MTH1 double-knockout lost 23 bp/PD.On the contrary, disruption of MTH1 or MTH1 and PRDX1 together reduced the elongation rate in 20% O2to 38 and 9–11 bp/PD, respectively. In 40% O2, telomeres shortened in the absence of MTH1, with faster shortening upon codisruption of PRDX1.When grown in the presence of 20% O2, TSQ1 repeat DNA incorporation was reduced in MTH1 knockout cells when compared with wild type, and a further reduction of the TSQ1 repeat DNA was obtained with the MTH1/PRDX1 double-knockout cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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