| Gene name: | RB1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | H1299,H460 |
| Gene ID: | 5925 |
| Category: | protein coding |
| Phenotype: | Lung cancer |
| Experimental category: | HL |
| PMID: | 29311118 |
| Experiment: | SA-β-gal activity assay |
| Description: | RB-proficient and RB-deficient H1299 and H460 cells were exposed to PD 0332991 for two weeks and analyzed for the expression of the senescence marker β-galactosidase activity. Interestingly, elevated levels of β-galactosidase activity were observed in RB-proficient cells in response to PD 0332991, while RB-deficient cells failed to induce β-galactosidase, suggesting an RB-dependent senescence program. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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