| Gene name: | CDKN2A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCEC |
| Experiment: | Immunostaining//qRT-PCR |
| Description: | Morphologically, the cells became flattened at Day 42 and floating at Day 49, suggesting an end replication and an end of cell life 20. During the period from Day 42 to Day 49 after the establishment of contact-inhibition in HCECs, there was continuous nuclear presence of p16INK4a and gradual upregulation of senescence markers such as ASF1A and GLB1. |
| Target gene: | BMI1 |
| Official symbol(s): | BMI1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//qRT-PCR |
| Target gene description: | The same results were held up by Day 42 following weekly knockdown of p120-Kaiso, resulting in unique downregulation of p16INK4a transcript but upregulation of Bmi1 transcript . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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