| Gene name: | NSUN2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | SA-β-gal activity assay//Western blot//Knockdown |
| Description: | Exposure of HUVECs to high glucose increased the levels of SHC, TP53, p16, and p-p38, the levels of cellular ROS, the percentage of G1 cells, and SA-β-gal activity, while knockdown of NSUN2 mitigated all of these effects. |
| Target gene: | SHC |
| Official symbol(s): | SHC1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Methylation |
| Target gene experiment: | Western blot//Knockdown |
| Target gene description: | Overexpression of NSUN2 increased the levels of SHC proteins p66SHC, p52SHC, and p46SHC (~3.9-, ~5.6-, and ~3.8-fold, respectively), while NSUN2 knockdown decreased the same (by ~70%, ~80%, and ~80%, respectively). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...