| Gene name: | SATB2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | B-MSC |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Although cellular proliferation remained largely unaltered, enforced SATB2 overexpression significantly enhanced pluripotency markers expression, whereas reduced cellular senescence as reflected by reduced SA-β-Gal-positive cells and senescence marker expression.The cellular proliferation rate significantly decreased after SATB2 knockdown. |
| Regulatory pathway: | NANOG |
| R-AG-Pathway: | Upregulation |
| Official symbol(s): | NANOG |
| Pathway experiment: | Knockdown//qRT-PCR//CHIP |
| Pathway description: | Our data reveal that the level of Nanog transcript was induced upon SATB2 overexpression, and reduced following SATB2 knockdown.Significant enrichment of SATB2 was identified in four putative binding sites in Nanog promoter region. |
Annotation:
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