| Gene name: | SIRT7 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NIH-3T3,U2OS |
| Experiment: | EdU assay//SA-β-gal activity assay |
| Description: | The SIRT7GFP overexpressing cells showed a significant decrease in EdU incorporation indicative of fewer S-phase cells at 14 and 18 h .The control GFP overexpressing cells showed significantly more number of SA-β-gal positive cells,while SIRT7GFP overexpressing cells were mostly SA-β-gal negative. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | We had noted that SIRT7GFP overexpressing cells when treated with doxorubicin at senescent inducing dose (0.25 mM for 2 h) showed lesser p53 accumulation compared to control. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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