| Gene name: | TRIM28 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | Crystal violet assay//Immunostaining//BrdU assay//SAHF//Knockdown |
| Description: | We observed that TRIM28 depletion resulted in increased cell growth upon OIS induction,similar to what was observed upon p53 knockdown.TRIM28 knockdown also resulted in less cells presenting features characteristic of senescence such as senescence-associated heterochromatic foci.A higher percentage of cells with depleted TRIM28 levels incorporated BrdU 6 days upon 4OHT induction, suggesting that depletion of TRIM28 partially prevented the effects of OIS. |
| Target gene: | P16 |
| Official symbol(s): | P16 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Immunostaining//knockdown |
| Target gene description: | p16INK4a levels were lower upon knockdown of TRIM28. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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