| Gene name: | SLC13A3 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MRC-5,WI-38 |
| Experiment: | SA-β-gal activity assay//Immunostaining |
| Description: | In the present study, the positive rate of SA-β-gal staining has reached 95% in the NaDC3-infected MRC-5 cells at PD 37, which was significantly increased than those in the uninfected and control vector infected cells. When examining cellular morphology of the infected cells, we observed significant senescent morphological changes in the NaDC3-infected cells. The results by DAPI staining showed that NaDC3 could also induce similar premature cellular senescence in the WI-38 cells. |
| Target gene: | NADH |
| Official symbol(s): | MT-ND1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | NAD+/NADH Quantitation kit//Confocal microscope |
| Target gene description: | NaDC3 overexpression markedly increased intracellular NADH levels compared with the two controls. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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