| Gene name: | GADD45A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | SCL-1 |
| Gene ID: | 1647 |
| Category: | protein coding |
| Phenotype: | Skin cancer |
| Experimental category: | L |
| PMID: | 29663367 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Compared with the blank group,these nescence of tumor cells was postponed in the siGadd45a group (p< 0.05), while significantly improved in the Nutlin-3 group (p< 0.05). No significant difference showed in senescence among the blank, NC, and siGadd45a + Nutlin-3 groups (all p> 0.05). Cells transfected with siGadd45a had postponed senescence. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Immunostaining |
| Target gene description: | The result showed that in the tumor tissues, the positive expression rate of mutant p53 was significantly higher than the normal group (all p< 0.05).Compared with the blank group, the positive expression rate of mutant p53 was significantly increased in the siGadd45a group (p< 0.05). The Nutlin-3 group presented decreased yellow granules, indicating that mutant p53 protein expression was decreased (p< 0.05). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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