| Gene name: | KIR2DL4 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NK |
| Experiment: | qRT-PCR |
| Description: | To test if TAK1 was required for the 2DL4-mediated SASP of resting NK cells, we stimulated resting NK cells with agonist Ab to 2DL4 for 16 h in the presence or absence of 1 mM TAK1 inhibitor. Quantitative RT-PCR was used to test the relative expression of a set of 10 genes that contribute to the senescent signature of primary NK cells. Upregulation of each of these 10 genes upon stimulation of NK cells with agonist Ab to 2DL4 was blocked in the presence of 1 mM TAK1 inhibitor . These results suggest that TAK1 is required for the SASP that results from the activation of primary NK cells by 2DL4. |
| Target gene: | TAK1 |
| Official symbol(s): | NR2C2 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR |
| Target gene description: | To test if TAK1 was required for the 2DL4-mediated SASP of resting NK cells, we stimulated resting NK cells with agonist Ab to 2DL4 for 16 h in the presence or absence of 1 mM TAK1 inhibitor. Quantitative RT-PCR was used to test the relative expression of a set of 10 genes that contribute to the senescent signature of primary NK cells. Upregulation of each of these 10 genes upon stimulation of NK cells with agonist Ab to 2DL4 was blocked in the presence of 1 mM TAK1 inhibitor. These results suggest that TAK1 is required for the SASP that results from the activation of primary NK cells by 2DL4. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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