| Gene name: | MIR503 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HPNE |
| Gene ID: | 574506 |
| Category: | ncRNA |
| Phenotype: | Pancreatic cancer |
| Experimental category: | L |
| PMID: | 28942143 |
| Experiment: | SA-β-gal activity assay//Flow cytometry//Colony formation assay |
| Description: | miR-503 mimic significantly promoted anchoragedependent colony formation, accelerated cell cycle progression, and decreased KRASG12D-induced senescence in HPNE/KRASG12D/shNC cells.miR-503 inhibitor significantly inhibited anchorage-dependent colony formation, retarded cell cycle progression, and increased cell senescence in HPNE/KRASG12D/shARID1A. |
| Target gene: | P16 |
| Official symbol(s): | P16 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | The expression of p16 was obviously decreased in HPNE/KRASG12D/ shNC cells upon the transfection of miR-503 mimic, whereas miR503 inhibitor led to increased p16 expression in HPNE/KRASG12D/ shARID1A cells, as shown by western blot assay. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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