| Gene name: | SUMO2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NPC |
| Gene ID: | 6613 |
| Category: | protein coding |
| Phenotype: | Disc degenerative disease |
| Experimental category: | L |
| PMID: | 29700214 |
| Experiment: | SA-β-gal activity assay |
| Description: | The positive rate of cell senescence in the model and NC groups were significantly higher than that in the sham group (p < 0.05). The positive rate of cell senescence in the shRNA group was significantly lower than that in the IDD group (p < 0.05). |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | qRT-PCR |
| Pathway description: | The mRNA and protein levels of SUMO2, p53, p21, MDM2, GADD45a, MMP-2, HIF-1α, and the p53 phosphorylation level of NPCs in the shRNA group were significantly lower than those in the IDD group (p < 0.05), but the mRNA and protein levels of CDK2/4 and CyclinB1 were significantly higher than that in the IDD group (p < 0.05). There was no significant difference observed between the model and NC group . |
Annotation:
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