| Gene name: | NGF |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Res 186,Res 259,U87,A172 |
| Experiment: | SA-β-gal activity assay |
| Description: | Microscopic analyses indicated that after 72 hr of exposure to NGF, the HGG cells showed an increase in SA‐β‐Gal positive staining compared with control, suggesting the induction of senescence. |
| Target gene: | P27//P21//CYCLIN D1//P53//P16 //RB |
| Official symbol(s): | P27//P21//CYCLIN D1//P53//P16 //RB |
| R-AG-Target gene: | Upregulation//Upregulation//Upregulation//Upregulation//Upregulation//Downregulation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | Western blot |
| Target gene description: | In our studies following NGF treatment in A172 cells (expressing p53) we observed p27, p21, cyclin D1, pp53, and p16 enhanced expression and the decrease of phospho‐Rb that directly or indirectly lead to accelerated cell senescence. |
| Regulatory pathway: | NF-κB |
| R-AG-Pathway: | Activation |
| Official symbol(s): | NFKB1 |
| Pathway experiment: | Western blot |
| Pathway description: | In addition, we have found the involvement of NF‐kB in promoting senescence in PLGG cells, in fact the NGF is able to activated NF‐kB signaling after 24 hr of treatment. |
Annotation:
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