| Gene name: | MIF |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MSC |
| Experiment: | qPCR//Cell morphological analysis |
| Description: | Moreover, when comparing cell morphology between MIF-overexpressing and the control cells, the control hMSCs displayed enlarged and flattened morphology, whereas the MIF-overexpressing hMSCs maintained spindle morphology.In addition, our real-time PCR results showed that the expression levels of p16 and p21 mRNA transcripts were significantly downregulated (P < 0.05) in MIF-overexpressing hMSCs compared to those in the control hMSCs. |
| Regulatory pathway: | AKT |
| R-AG-Pathway: | Activation |
| Official symbol(s): | AKT1 |
| Pathway experiment: | Western blot |
| Pathway description: | In addition to increased expression of MIF, our western blot results also showed that the levels of total and phosphorylated AKT were increased in MIF-overexpressing hMSCs than those in the control cells. |
Annotation:
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