| Gene name: | HMGA1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis//Western blot//SAHF |
| Description: | Cells expressing high levels of either HMGA protein underwent an acute cell cycle arrest and displayed features of senescence, including increases in p16INK4a and p53, a senescent morphology, and elevated SA-β-galactosidase activity.These cells also acquired SAHF-like foci that contained HMGA and me-K9H3. |
| Target gene: | P16 |
| Official symbol(s): | P16 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | HMGA1-induced arrest and SAHF formation were clearly impaired in cells expressing sh-p16, despite having similar levels of transgene expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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