Aging Overview

Aging gene

Gene name: WNT7A
Aging type: Accelerate
Aging characteristic:
Tissue type: Lung
Cell name: A549
Gene ID: 7476
Category: protein coding
Phenotype: Lung cancer
Experimental category: HL
PMID: 25728679
Experiment: SA-β-gal activity assay//CCK-8 assay
Description: Histological analysis of the lung sections of the wild-type and Wnt7a-null mice showed no difference in basal staining for SA-β-gal activity. However, a large number of SA-β-gal-positive cells, predominantly in the tumor area, were observed in lung sections of the wild-type mice after urethane treatment, whereas Wnt7a-null mice,on the contrary, showed reduced or no SA-β-gal staining.


Regulatory relationship

Regulatory pathway: SKP2-P27-PRB
R-AG-Pathway: --
Official symbol(s): SKP2-PSMD9-RB1
Pathway experiment: Western Blot
Pathway description: Consistent with the changesin SKP2 and p27kip1 expression, the levels of phosphorylated(p-Rb-S780) retinoblastoma proteins in Wnt7a-null mice were dramatically increased as well . Cyclin D1, which is critical for Ser780 phosphorylation of Rb ,was also upregulated in Wnt7a-null mice, along with CDK2 andCDK6, components of the CDK/cyclin complex . Similarresults were obtained when using the lung lysates of wild-typeand Wnt7a-null in FVB/NJ mice.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view

About risk SNP and eQTL

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