| Gene name: | PDZD2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | DU 145 |
| Gene ID: | 23037 |
| Category: | protein coding |
| Phenotype: | Prostate cancer |
| Experimental category: | L |
| PMID: | 18639375 |
| Experiment: | SA-β-gal activity assay |
| Description: | Furthermore, 108 and 107 M sPDZD2 induced senescence of DU145 cells after 6 days of incubation. |
| Target gene: | P21/WAF1 |
| Official symbol(s): | P21/WAF1 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Similarly, up-regulation of p21CIP1/WAF1 expression to 2.6-, 2.9- and 3.2-fold were observed after the cells were treated with 109, 108 and 107 M sPDZD2, respectively. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | Upregulation |
| Official symbol(s): | TP53 |
| Pathway experiment: | Western blot |
| Pathway description: | Treatment of MCF-7 cells with 108 and 107 M sPDZD2 for 48 h resulted in 2.4- and 2.2-fold increases in p53. |
Annotation:
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