| Gene name: | GDF11 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HFL-1,Primary bronchial epithelial cell |
| Gene ID: | 10220 |
| Category: | protein coding |
| Phenotype: | Chronic obstructive pulmonary disease |
| Experimental category: | L |
| PMID: | 28455454 |
| Experiment: | SA-β-gal activity assay//Western blot//Cell counting |
| Description: | Treatment with GDF11 significantly inhibited the CSE-augmented expression of p16 and p53 and the CSE-augmented SA-β-gal activity in a concentration-dependent manner. CSE significantly delayed cell proliferation, but treatment with GDF11 ameliorated the delay in cell growth. Similar anti-senescent effects of GDF11 were observed in primary bronchial epithelial cells. Treatment with GDF11 significantly ameliorated the CSE-induced cellular senescence as assessed by the expression of senescence-associated proteins, SA-β-gal activity and cell proliferation.These results suggest that GDF11 could prevent cigarette smoke from accelerating lung cellular senescence. |
| Regulatory pathway: | SMAD2/3 |
| R-AG-Pathway: | -- |
| Official symbol(s): | SMAD2-SMAD3 |
| Pathway experiment: | Western blot |
| Pathway description: | As previously reported in other types of cells,GDF11 phosphorylated Smad2/3,and the phosphorylation was inhibited by an activin receptor-like kinase (ALK)4/5 inhibitor, SB431542, in HFL-1 cells. |
Annotation:
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