| Gene name: | FBXO46 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF-7 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | It was observed that depletion of FBXO46 significantly increased the population of senescent cells, which was inhibited upon co-depletion with FBXO31. |
| Target gene: | FBXO31 |
| Official symbol(s): | FBXO31 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Phosphorylation |
| Target gene experiment: | Western blot//Co-IP |
| Target gene description: | Immunoblot analysis revealed the presence of FBXO46 in the FBXO31 immunoprecipitates. In a reciprocal co-immunoprecipitation assay, FBXO31 was found to be present in the FBXO46 immunoprecipitates, suggesting that FBXO46 and FBXO31 interact with each other.The results showed that FBXO46 significantly decreased FBXO31 levels in a dose- dependent manner. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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