| Gene name: | HDAC1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HeLa |
| Gene ID: | 3065 |
| Category: | protein coding |
| Phenotype: | Cervical cancer |
| Experimental category: | L |
| PMID: | 21420382 |
| Experiment: | SA-β-gal activity assay//Western blot//Cell morphological analysis |
| Description: | Some characteristics of senescence, including an enlarged and flattened morphology, positive staining for SA-β-galactosidase activityand increased autofluorescence, were observed in HDAC1 over-expressing cells;cells expressing high levels of HDAC1 immediately suppressed cell division. |
| Regulatory pathway: | SP1-PP2A-PRB |
| R-AG-Pathway: | -- |
| Official symbol(s): | SP1-PPP2R4 |
| Pathway experiment: | Western blot//Luciferase reporter assay//Chromatin-immunoprecipitation assay |
| Pathway description: | An approximately 3-fold induction increase in the activity of the PP2Ac promoter in the presence of Sp1;HDAC1-overexpressing cells exhibited a dose-dependent inhibition of pRb1;HDAC1 activated the promoter activity of PP2Ac and increased protein expression of PP2Ac. |
Annotation:
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