| Gene name: | HIF1A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | SA-β-gal activity assay//Flow cytometry//Knockdown//Western blot |
| Description: | The knockdown of HIF-1α also strongly suppressed the conversion of the growth-arrested state in Ni-treated cells into senescence,HIF-1α enhanced protein expression of the CDK inhibitor p21 but moderately diminished upregulation of p53 protein or its Ser15 phosphorylation by Ni. we found that its knockdown helped preserve the expression of the S/G2-specific cyclin A at the midrange of our Ni doses and inhibited upregulation of the CDK inhibitor p27. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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