Aging Overview

Aging gene

Gene name: TERF2
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: AG06814,GM00319,AG00780,AG03141
Gene ID: 7014
Category: protein coding
Phenotype: Werner syndrome
Experimental category: L
PMID: 18212065
Experiment: Cell morphological analysis//SA-β-gal activity assay
Description: Notably,greater than 80% of Flag-TRF2△B△M-expressing fibroblasts showed a replicative senescence-like phenotype, exhibiting a flattened morphology, and stained positive for SA-β-gal activity.


Regulatory relationship

Target gene: WRN
Official symbol(s): WRN
R-AG-Target gene: --
Subcategory: Unclear
Target gene experiment: Western blot//SA-β-gal activity assay
Target gene description: Eight days after transduction, 70% of the wild-type WRN-complemented WS fibroblasts expressing Flag-TRF2△Bstained positive for SA-βgal, demonstrating that TRF2△B-induced cellular senescence was reconstituted by the expression of a functional WRN protein. In contrast, overexpression of Flag-TRF2△B failed to increase the percentage of SA-βgal-positive cells in the lines expressing WRN variants lacking helicase, exonuclase, or both activities.

Regulatory pathway: P53-P21
R-AG-Pathway: Upregulation
Official symbol(s): TP53-CDKN1A
Pathway experiment: Western blot
Pathway description: Western blot analysis shows that p53 and its downstream target, p21, are upregulated in normal fibroblasts expressing Flag-TRF2△B△M.


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



Pathway view

About risk SNP and eQTL

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