| Gene name: | ATM |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HPr-1 |
| Experiment: | Western blot |
| Description: | Examination of cH2AX expression revealed that knockdown of ATM or ATR both suppressed the induction of cH2AX by androgen treatment, suggesting that the androgen-induced DNA damage response was significantly suppressed by ATM/ATR knockdown. |
| Target gene: | CDC25A |
| Official symbol(s): | CDC25A |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Knockdown of ATM, but not ATR, partially recovered the CDC25A protein expression in LNCaP cells, suggesting that downregulation of CDC25A by androgen requires the activation of ATM. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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