| Gene name: | ERBB2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF 10A |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis//Growth curve assay |
| Description: | We expressed HER2 in HSF1-depleted cells, a significant growth inhibition was observed, associated with a significant change in cells’ appearance, including enlarged, flattened morphology and extensive vacuolization reminiscent of senescence.HER2 expression in control MCF-10A cells led to a significant increase in β-gal-positive population (B30%). |
| Target gene: | P21//SURVIVIN |
| Official symbol(s): | P21//SURVIVIN |
| R-AG-Target gene: | Upregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Co-IP |
| Target gene description: | P21 was mildly upregulated by HER2 expression in control cells.Upon HER2 expression, survivin levels were dramatically decreased in shHSF1 cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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