Aging Overview

Aging gene

Gene name: LMNA
Aging type: Accelerate
Aging characteristic:
Tissue type: Umbilical cord blood
Cell name: MSC
Gene ID: 4000
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 29760459
Experiment: Western blot//SA-β-gal activity assay//MTT assay
Description: Immunoblots confirmed the over-expression of GFP-progerin and increased expression of p16INK4a, a marker of senescence in hMSCs;Induction of cellular senescence was also confirmed by the increase in SA-β-gal activity;MTT activity was decreased in response to progerin over-expression, indicating decreased proliferative activity.


Regulatory relationship

Target gene: MCP-1//NF-?B
Official symbol(s): CCL2//NFKB1
R-AG-Target gene: Upregulation//Upregulation
Subcategory: Unclear
Target gene experiment: qRT-PCR//ELISA//Western blot//Immunostaining
Target gene description: Except for MCP-1, most cytokines that have been reported to increase in senescent fibroblasts were not increased in senescent hMSCs expressing progerin.The secretion of MCP-1 was also increased in the CM from progerin-expressing cells.The activation of NF-?B was also increased in response to progerin expression.

Regulatory pathway: --
R-AG-Pathway: --
Pathway experiment: --
Pathway description: --


Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.



About risk SNP and eQTL

Loading,please wait...