| Gene name: | HMGB2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | Knockdown//qRT-PCR//Western blot//SA-β-gal activity assay |
| Description: | We validated that HMGB2 expression was decreased at both the mRNA and protein levels during senescence of normal primary human embryonic fibroblast IMR90 cells induced by oncogenic RAS.knockdown or knockout of HMGB2 induced senescence in IMR90 cells . |
| Target gene: | C/EBP-β |
| Official symbol(s): | CEBPB |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//CHIP-seq//CHIP//qRT-PCR |
| Target gene description: | C/EBP-β is a direct target gene of HMGB2 in senescent cells, and knockdown of HMGB2 decreased C/EBP-β gene expression.Loss of HMGB2 allows for spreading of heterochromatin marks and promotes the inclusion of SASP gene loci into SAHF, which in turn represses SASP gene expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...