| Gene name: | IRS2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Brain |
| Cell name: | Astrocyte |
| Gene ID: | 8660 |
| Category: | protein coding |
| Phenotype: | Huntington disease |
| Experimental category: | L |
| PMID: | 21926467 |
| Experiment: | Survival curve |
| Description: | The body weights of R6/2?Irs2ntg mice increased normally until 7 weeks, but afterward declined rapidly, and half the mice died between 11 and 12 weeks of age. Based on Cox regression,neuronal Irs2 in R6/2?Irs2ntg mice significantly increased the risk of death 3.6-fold compared with R6/2 mice;sex of the mice was not a significant covariate.The fore limb grip of R6/2 and R6/2?Irs2ntg mice was significantly weaker than those of control and R6/2?Irs2+/–?Irs2βtg mice. |
| Target gene: | FOXO1 |
| Official symbol(s): | FOXO1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | The fractionation of brain homogenates and immunoblotting confirmed that phosphorylated FoxO1 was largely cytoplasmic in R6/2 and R6/2?Irs2ntg mice, whereas FoxO1 was weakly phosphorylated and most strongly detected in the nuclear (laminin-containing) fractions from R6/2?Irs2+/–?Irs2βtg brains. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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